PRAX-944 Demonstrates Functional Improvement in ET Patients
In May 2022, Praxis Precision Medicines announced positive results from their PRAX-944 Phase 2a study. The primary objective of the study was to demonstrate safety and efficacy of the PRAX-944 compound in the treatment of essential tremor.
In the study, treatment with PRAX-944 resulted in clinically meaningful improvements in function, which were supported by improvements in tremor severity. The study included an open-label period, in which all participants were treated with PRAX-944; the results demonstrated an average improvement of 42% in the Modified Activities of Daily Living (ADL) score as compared to ADL scores prior to treatment with the PRAX-944 compound.
“The data from the PRAX-944 Phase 2a study offer hope to people living with essential tremor, for a treatment developed specifically for ET,” said Bernard Ravina, M.D., Chief Medical Officer at Praxis.
Praxis is currently running a Phase 2b study evaluating the safety of the PRAX-944 compound. This study is called the Essential1 Study and it is enrolling new patients. If you or someone you know is interested in learning more about participating, go online to schedule a call with a Clinical Trial Patient Navigator.
Running 100 Miles for ET Awareness
Most people could not imagine taking on the challenge of running 100 miles. But Peder Nelson has signed up twice!
In the fall of 2023, this Sellersburg, IN resident will participate in his second Cloudsplitter 100 ultra-marathon. Cloudsplitter takes place in the heart of Central Appalachia in the Cumberland Mountains of Virginia. It’s described as “one of the more physically demanding trails in the East.” Peder will be running to raise awareness to essential tremor and to support the mission of the International Essential Tremor Foundation.
Peder talks about his goals, how he is preparing for this run and shares his personal essential tremor story in our latest Talking Essential Tremor podcast, Running 100 Miles for ET Awareness.
In 2019, Peder attempted his first Cloudsplitter with the goal of raising $10,000 for the IETF. He fell short when he suffered ankle injuries during the race. Nonetheless, he raised a significant amount: more than $4,300.
Follow Peder’s story and journey on his Difficult Destinations Facebook page.
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ET Trailblazers are dedicated to finding answers and lending critical support to the ET community. Their generous monthly contributions allow us to respond quickly to grant and research opportunities and develop helpful programs and outreach services.
Please join the Trailblazers today by becoming a monthly donor to the IETF. It’s convenient for you because you won’t have to worry about initiating an annual donation, and you’ll never miss an issue of Tremor Talk magazine. Plus, you’ll be making a significant and ongoing impact on the lives of people coping with ET.
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