Compound May Hold Promise as Therapy for ET
Results are promising from a two-year research study evaluating a GABA receptor drug as potential therapy for essential tremor.
Dr. Adrian Handforth, with the Veterans Affairs Greater Los Angeles Healthcare System, headed up the study which received a 2019 research grant from the International Essential Tremor Foundation.
The drug known as Compound 6 selectively activates only alpha6-beta-gamma2 receptors and has already been shown to affect cerebellar granule cell function when injected systemically but until this study had not been tested on tremor. GABA is the brain’s main inhibitory neurotransmitter, and it works by activating GABA receptors. Brain GABA receptors are not uniform but differ according to their subunit composition. They all contain 2 alpha subunits, of which there are 6 types, 2 beta (3 types), and either a delta (only 1 type) or a gamma (3 types) subunit. Cerebellar granule cells contain most of the brain’s alpha6-beta-delta receptors.
The study found that Compound 6 effectively suppresses harmaline tremor (an induced tremor) at doses in the well-tolerated range, suggesting that Compound 6 may exert clinical efficacy for essential tremor at well-tolerated doses. The results also imply that the Compound enters the brain and exerts efficacy within minutes, and suppresses tremor for up to an hour in mice.
The results indicate that Compound 6 holds promise in the treatment of ET. These findings represent an early step. More needs to be known about the safety and binding profile of this interesting compound and others in its class.
Read the entire study online.
Reducing the Burden of Brain Disorders through Education and Advocacy
Brain disease affects more people than heart disease and cancer combined. That’s why it’s so important to advance the understanding of the functions of the brain and reduce the burden of brain disorders through public education and advocacy. This is the role of the American Brain Coalition (ABC), of which the IETF is a member.
In our latest Talking Essential Tremor podcast, Katie Sale, executive director of the ABC, talks about the ABC’s advocacy work. She also discusses the BRAIN Initiative and what it means for people with movement disorders.
Learn more by tuning into, “Partnering with the American Brain Coalition for ET Advocacy.”
Are there topics you would like to see covered in an upcoming Talking Essential Tremor podcast? Email your suggestions to Marketing & Communications Manager Tammy Dodderidge, firstname.lastname@example.org.
Download Our ET Coping Tips Handout
Essential tremor can turn daily tasks into a test of ingenuity, perseverance and self-esteem. Dressing, eating, applying makeup, brushing your teeth – all of these things can lead to frustration and anxiety, and also increased tremor.
The IETF has compiled a list of everyday coping tips, many of which have been shared by those in the ET community. It includes general suggestions as well as suggestions for writing, eating/drinking, food preparation, using technology, airport security and more.
You can download it free from our website.