Principal Investigator: Dr. Esther Krook-Magnuson, University of Minnesota, Minneapolis Propranolol is a beta-blocker and is the most widely used medication for the treatment of essential tremor. Dr. Krook-Magnuson believes propranolol’s actions are centrally located, working on a region of the brain known as the cerebellum, and slowing the amount of norepinephrine released. Norepinephrine is a […]
Principal Investigator: Prof. Gregor Kuhlenbäumer, Kiel University, Germany The analysis and quantification of tremor is achieved by using a tremor measuring device called an accelerometer. However, accelerometry is not widely available and only a few centers have them available. Modern smartphones and smartwatches usually contain 3 sensors which might be suitable to analyzed tremor: (1) […]
Shen-Han Kuo A neuron is a specialized cell in the brain that processes and transmits information through electrical and chemical signals. These electrical and chemical signals travel between neurons by way of specialized connections with other cells. Each neuron is capable of making numerous connections, becoming a vast network of cells. The signals that each […]
Principle Investigator: Adrian Handforth, MD “People tend to think of medical marijuana as a single substance; a substance that may have beneficial effects but also causes mood- and mind-altering effects,” explains Dr. Adrian Handforth, Assistant Chief of Neurology at VA Greater Los Angeles Healthcare System in California, “But that is not the case at all. […]
Nicholas Franich We have just begun to understand the inner-workings of the brain and how different parts of the brain communicate information to the body. Dr. Nicholas Franich, Assistant Project Scientist at the David Geffen School of Medicine at the University of California in Los Angeles, seeks to test one possible cause of essential tremor. […]
A Feasibility Study for an Essential Tremor Brain Bank at the Arizona Study of Aging and Neurodegenerative Disorders Now in its third IETF-funded year, researchers will continue to examine the brain tissue of those with ET and other neurological disorders after death, searching for a greater understanding of how ET changes the features of the […]
Cerebello-Thalamo-Cortical Coupling in Essential Tremor: Effects of High-Frequency Cerebellar Stimulation on Brain Activity and Tremor Although the cause and development of ET is not fully explained, tremor is associated with abnormal activity within different brain regions, particularly the thalamus and cerebellum. Deep Brain Stimulation (DBS) reverses symptoms of tremor but is an invasive procedure. Transcranial […]
The cause and development of ET remains poorly understood. Functional imaging studies show cerebellar abnormalities in patients living with ET. The goal of this research is to investigate the role of excitotoxicity in the postmortem essential tremor cerebellum. Excitotoxicity is the pathological process by which nerve cells are damaged and killed by excessive stimulation by […]
Essential Tremor Brain Bank at the Arizona Study of Aging and Neurodegenerative Disorders A grant funded by the IETF, in the amount of $35,000, was awarded to Holly Shill, MD, Director, Christopher Center for Parkinson Research, Cleo Roberts Center for Clinical Research, and to Charles H. Adler, Co-PI and Clinical Core Director of the Arizona […]
An Innovative Damping Exoskeleton Approach to Essential Tremor Treatment Carlo Menon, PhD, Simon Fraser University, Burnaby, BC, CANADA was awarded an IETF research grant in the amount of $24,992 for his proposal entitled, “An innovative damping exoskeleton approach to essential tremor treatment”. This project explores a new assistive device for essential tremor using state-of-the-art wearable […]