BOSTON, June 09, 2023 (GLOBE NEWSWIRE) — Praxis Precision Medicines, Inc. (NASDAQ: PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced the outcomes from a recent end-of-Phase 2 meeting with the U. S. Food and Drug Administration (FDA) regarding plans to advance ulixacaltamide into Phase 3 for essential tremor (ET).
Praxis Precision Medicines Announces Plans to Begin Ulixacaltamide Phase 3 in Essential Tremor
Posted on June 12, 2023
Categories: ET Treatment, In the News
Is the Ulixacaltamide the same as PRAX-944 which has been mentioned before?
Yes. They have given it a name. A phase 3 clinical trial is in the planning. You can read more about it through this press release just published this week. https://essentialtremor.org/wp-content/uploads/2023/06/Praxis-Precision-Medicines-Announces-Plans-to-Begin-Ulixacaltamide-Phase-3-in-Essential-Tremor-by-Year-End-After-Completing-End-of-Phase-2-Meeting-with-FDA.pdf
Has frequent long term (2-3 months) HBOT therapy proven to be beneficial for people afflicted with ET (possibly due to neuroplasticity effects)?
Have any reports of HBOT trials undertaken for relief of ET been made available?
The IETF has not been involved in a study regarding the impact of HBOT therapy on ET so we can’t answer that. There have been studies done on its impact on brain injury (here is a link to that study: https://bmjopen.bmj.com/content/8/9/e023387). HBOT has traditionally be used to treat hypoxia-related conditions. There is a study that discusses therapeutic aspects of HBOT on neurologic conditions. Here is the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564723/).
Are there any further reports available on the efficacy of legal medicinal cannabis for the treatment of ET?
There have been a couple of studies completed and the results showed that cannabinoids did not reduce essential tremor amplitude. Here are links to the two studies:
https://pubmed.ncbi.nlm.nih.gov/33465546/#:~:text=In%20conclusion%2C%20a%20single%20300,Cannabidiol%3B%20Essential%20tremor%3B%20Treatment
https://clinicaltrials.gov/ct2/show/study/NCT03805750